| Epididymis | |
|---|---|
| 1: Epididymis 2: Head of epididymis 3: Lobules of epididymis 4: Body of epididymis 5: Tail of epididymis 6: Duct of epididymis 7: Deferent duct (ductus deferens or vas deferens) |
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| The right testis, exposed by laying open the tunica vaginalis. | |
| Gray's | subject #258 1242 |
| Vein | Pampiniform plexus |
| Precursor | Wolffian duct |
| MeSH | Epididymis |
The epididymis ( /ɛpɨˈdɪdɨmɪs/; plural: epididymides /ɛpɨˌdɪdɨˈmiːdiːz/) is part of the male reproductive system and is present in all male amniotes. It is a narrow, tightly-coiled tube connecting the efferent ducts from the rear of each testicle to its vas deferens. A similar, but probably non-homologous, structure is found in cartilaginous fishes.
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The epididymis can be divided into three main regions
In reptiles, there is an additional canal between the testis and the head of the epididymis, which receives the various efferent ducts. This is, however, absent in all birds and mammals.[1]
The epididymis is covered by a two layered pseudostratified epithelium. The epithelium is separated by a basement membrane from the connective tissue wall which has smooth muscle cells. The major cell types in the epithelium are:
Spermatozoa formed in the testis enter the caput epididymis, progress to the corpus, and finally reach the cauda region, where they are stored. Sperm entering the caput epididymis are incomplete - they lack the ability to swim forward (motility) and to fertilize an egg. During their transit in the epididymis, sperm undergo maturation processes necessary for them to acquire these functions.[3] Final maturation is completed in the female reproductive tract (capacitation).
During ejaculation, sperm flow from the lower portion of the epididymis (which functions as a storage reservoir). They have not been activated by products from the prostate gland, and they are unable to swim, but are transported via the peristaltic action of muscle layers within the vas deferens, and are mixed with the diluting fluids of the seminal vesicles and other accessory glands prior to ejaculation (forming semen).
The epithelial cells of the epididymis possesses numerous apical modifications that are often referred to as stereocilia, as under the light microscope they look like cilia. However, as electron microscopy has revealed them to be structurally and functionally more similar to microvilli, some now refer to them as stereovilli.[4]
An inflammation of the epididymis is called epididymitis. It is much more common than orchitis.
A Gartner's duct is a homologous remnant in the female.
In the embryo, the epididymis develops from tissue that once formed the mesonephros, a primitive kidney found in many aquatic vertebrates. Persistence of the cranial end of the mesonephric duct will leave behind a remnant called the appendix of the epididymis. In addition, some mesonephric tubules can persist as the paradidymis, a small body caudal to the efferent ductules.
Epididymectomy is the surgical removal of the epididymis sometimes performed for Post-Vasectomy Pain Syndrome.
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